Paris St Germain will play Borussia Dortmund and Barcelona were pitted against an unpredictable Napoli, while Chelsea were drawn against Bayern Munich. City, who will be at home in the second leg, have yet to beat the Spanish side with two draws and two defeats in their previous four meetings.
Holders Bayern Munich will face nine-time champions Real Madrid in the Champions League semi-finals while 2012 champions Chelsea will play Atletico Madrid.
Bayer Leverkusen beat Freiburg 3-2 to edge closer to a first ever Bundesliga title.
Luis Suarez has agreed a deal with the club to end his contract and settled on personal terms with Atletico Madrid,
Diego Simeone called on his Atletico Madrid side to show their true colours when they face La Liga leaders Barcelona on Saturday in a crucial title clash.
Man United were mistakenly drawn with Villarreal, even though both teams had already faced each other in the group stage.
Bayern Munich will be without winger Serge Gnabry for their Champions League group game against Atletico Madrid on Wednesday after he tested positive for COVID-19, the German champions said on Tuesday.
IMAGES from the UEFA Champions League matches played on Wednesday.
Atletico Madrid coach Diego Simeone, a month on from a second Champions League final defeat to Real Madrid in three years, has made it clear that his immediate future is with the Spanish club. The Argentine, who has been at Atletico since 2011 and is under contract for another four years, said after the loss on penalties to Real that he wanted to explore his options. But now he says he is only concentrating on making the team better. "I spoke in the heat of the moment," Simeone told reporters on Wednesday in Buenos Aires. "We Argentinians are like that. Others are not at fault for beating you, I learned that a long time ago.
With a game in hand, Hansi Flick's Barca are top on 66 points, three ahead Real in second
Barcelona gave up more ground to Real Madrid in La Liga's title race on Tuesday after being held to a 2-2 draw at home to third-placed Atletico Madrid as a late penalty from Saul Niguez cancelled out Lionel Messi's 700th career goal. The draw meant the Catalans stayed second in the standings on 70 points and leaders Real Madrid, who have 71, will go four points clear at the top with five games left if they beat Getafe at home on Thursday.
IMAGES from football matches played across Europe on Wednesday.
Real Madrid swatted aside Granada 4-1 on Thursday to ensure the La Liga title race will go down to the wire.
Atletico Madrid got in the mood for Tuesday's Champions League quarter-final with Barcelona by thrashing Real Betis 5-1 on Saturday, their biggest win of the season. A classy finish from Fernando Torres and a fortuitous strike from Atletico's top scorer Antoine Griezmann gave the home side a 2-0 lead at halftime. Substitute Angel Correa then made a big impression in the second period, laying on the third goal for Juanfran and the fourth by Griezmann before Thomas Partey rounded off the scoring for the home team. Ruben Castro netted for Betis in the 79th minute when he pounced on a rare error from Atletico goalkeeper Jan Oblak.
UEFA to not place sanctions on PSG
Real Madrid manager Carlo Ancelotti heaped praise on his striker Kylian Mbappe after he scored a hat-trick in a 3-1 win over Manchester City on Wednesday that took the Champions League holders into the last 16.
Girona thrash Osasuna for first win of the season
Atletico meet city rivals Real Madrid in the final at Jeddah.
A first-half penalty earned Lille a shock 1-0 home victory over holders Real Madrid in the Champions League group phase on Wednesday.
IMAGES from football matches played across Europe on Wednesday.
Chelsea outplay Villa in FA Cup
Juve forward Cristiano Ronaldo had an unusually quiet game after scoring a hat-trick against Atletico in last year's competition, although he came within inches of grabbing a last-gasp winner when he sent a shot just past the far post.
Ernesto Valverde's Bilbao team punished the visitors with clinical counter-attacks, playing with the advantage of having won the first leg 1-0 in Madrid.
Chelsea have the upper hand ahead of next week's Champions League semi-final, second leg after holding Atletico Madrid to a frustrating 0-0 draw in Tuesday's first leg.
Antoine Griezmann and Samuel Lino scored in each half to give Atletico Madrid a 2-0 win over Lazio on Wednesday that secured them top spot in Champions League Group E, the first time since 2016 that they had reached the knockouts as group winners.
Striker Robert Lewandowski scored a first-half penalty to give Barcelona a hard-fought 1-0 home win over Rayo Vallecano.
Second-half strikes by Federico Valverde, Brahim Diaz and Endrick gave feeble Real Madrid an unconvincing 3-0 win over lowly Real Valladolid.
Their limp performance does not inspire confidence ahead of the visit of the all-powerful Serie A leaders and familiar foe Cristiano Ronaldo.
Manchester City came out on top in an epic Champions League battle against Monaco whereasAtletico Madrid beat hosts Bayer Leverkusen 4-2 in a topsy-turvy encounter.
A summary of Wednesday's action in the UEFA Champions League Knock-out phase play-offs.
Lionel Messi drew vast crowds and showed flashes of his brilliance when his Inter Miami side were held to a goalless draw by African giants Al-Ahly as the revamped Club World Cup got off to a festive start on Saturday.
The Catalonian side put up a good fight to stay level in the first half at a half-empty Wanda Metropolitano stadium, with Lucas Hernandez hitting the post and Diego Costa denied when one-on-one with the visiting keeper.
Watford knocked out of FA Cup; third-tier side Cultural Leonesa shock Madrid team.
Barcelona, Atletico Madrid and Real Madrid resume a nail-biting La Liga title race on Saturday after all notched up victories on Wednesday. Leaders Barcelona, who ended a four-game winless streak by hammering Deportivo La Coruna 8-0 away from home, host struggling Sporting Gijon on Saturday. Atletico battled to a 1-0 win at Athletic Bilbao to stay level on 79 points with Barcelona, who top the table with a superior head-to-head record and host Malaga. Real stayed one point behind their title rivals after beating Villarreal 3-0 and are expected to be without top scorer Cristiano Ronaldo for their visit to struggling neighbours Rayo Vallecano. The Portuguese forward was unable to finish the game against Villarreal after suffering cramp in stoppage time but eased concerns he had suffered a serious injury.
Atletico Madrid celebrated like they had won the trophy after reaching the Champions League quarter-finals by edging past PSV Eindhoven 8-7 on penalties on Tuesday following 210 goalless minutes in their last-16 tie.
The Catalan side said they will be presented with the league trophy on Friday during a special celebration in the city.
Atletico Madrid coach Diego Simeone is renowned for his wild touchline antics but a shrewd tactical move with a triple substitution swung Wednesday's Champions League game against Juventus firmly his side's way.
Real's victory at the Santiago Bernabeu means they are poised to knock Atletico out of the competition for the fourth successive year.
Holders Real Madrid will need to maintain their intensity for the whole of next week's return leg if they are to get past Atletico Madrid into the Champions League semi-finals, coach Carlo Ancelotti said on Tuesday.
Atletico Madrid's Luis Suarez struck two late goals to give the LaLiga champions a 2-1 win at Getafe on Tuesday after the hosts were reduced to 10 men late in the second half.
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